WebOct 15, 2024 · CircHIPK2 or VEGFA 3ʹUTR fragments (including putative binding sites or mutation sites of miR-1249–3p) were cloned into pMIR-REPORT vector (Promega, WI, … WebApr 5, 2024 · Upon ischemic insult, the gene downstream of circHIPK2, spermine oxidase Smox, is increased and mediates the scavenging of ROS. Indeed, Smox silencing in NSCs leads to amelioration of the stroke pathology and increased neurogenesis. These results suggest that gene manipulation of NSCs for enhancement of cell replacement might …
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WebOct 15, 2024 · CircHIPK2 in tumor tissue samples (DDP-sensitive and DDP-resistant) and normal tissues was detected for the first time. The outcomes displayed that circHIPK2 was upregulated in tumor tissues, particularly in DDP-resistant tissues (Fig. 1A).Subsequently, a significant increase in IC50 values in the two drug-resistant strains (A549/DDP and … WebCircHIPK2 has been found remarkably upregulated in nasopharyngeal carcinoma (NPC) tissues . In vitro and in vivo studies in animal models showed that circHIPK2 promotes proliferation of NPC cells while knockdown of circHIPK2 dampens the growth of NPC cells . Mechanistically, circHIPK2 downregulated HIPK2 at the protein levels and consequently ... grocery stores in westchester il
Silencing of circular RNA HIPK2 in neural stem cells enhances ...
WebQuantitative analysis of mRNAs, gene microarray hybridization, immunofluorescence, luciferase reporter assay, proliferation assay, EDU staining, subcellular location analysis … WebJan 15, 2024 · CircHIPK2 increased SIGMAR1 expression by suppressing miR-124-2HG activity . In bladder cancer, circHIPK3 affected the expression of heparanase by competitively binding to miR-558 [ 23 ]; circRNA MYLK and lncRNA H19 increase the expression of DNMT3, VEGFA, and ITGB1 by suppressing miR-29a-3P activity [ 24 ]. WebFeb 1, 2024 · The dynamic changes of circHIPK2 during the differentiation of NSCs were detected. As shown in Fig. 1a, the expression of circHIPK2 in NSCs was highest at the first day during NSC differentiation and decreased by 50% at 14 d, which suggested that circHIPK2 expression decreased with time during the differentiation of NSCs. To further … grocery stores in west branch mi