WebMay 10, 2024 · Cisplatin is a platinum-based chemotherapeutic that damages genomic DNA leading to cell death. It also damages mitochondrial DNA and induces high levels of mitochondrial reactive oxygen species (mtROS), further sensitising cells to apoptosis. Notably, immature oocytes are particularly vulnerable to cisplatin treatment, a common … WebJul 6, 2016 · Cisplatin (cis diamminedichloroplatinum II, cDDP) is one of the most effective cancer chemotherapeutic agents and is used in the treatment of many types of human malignancies. However, inherent tumour resistance is a major barrier to effective cisplatin therapy. So far, the mechanism of cDDP resistance has not been well defined.
Mitochondrial DNA alterations may influence the cisplatin ... - Nature
WebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. Semaglutide is a human glucagon-like peptide-1 receptor agonist (GLP-1R), which is used primarily for the treatment of DM. WebJul 14, 2024 · Here we have extended this strategy by coordinating in the axial positions of kiteplatin ( [PtCl₂ ( cis -1,4-DACH)], DACH = Diaminocyclohexane) and its CBDCA (1,1-cyclobutanedicarboxylate) analogue the antioxidant α-Lipoic acid (ALA), an inhibitor of the mitochondrial pyruvate dehydrogenase kinase (PDK). peterborough philatelic society
The role of natural antioxidants in cisplatin-induced …
WebJul 1, 2024 · Background: Cisplatin resistance is one of the main causes of treatment failure and death in head and neck squamous cell carcinoma (HNSCC). A more comprehensive understanding of the cisplatin resistance mechanism and the development of effective treatment strategies are urgent. WebJan 9, 2024 · Cancer Drug 49 Times More Potent than Cisplatin ... business news WebNext, synergistic effect of cisplatin combined with ZD55-MnSOD on ovarian cancer cell SKOV-3 was quantified by combination index (CIN) analysis and expressed as CIN versus fraction affected in Figure 2B. These results showed that the combination of cisplatin and ZD55-MnSOD has an enhanced tumor killing effect. starfrit the rock induction 8