Daptomycin and myopathy

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August undefined, 2024

WebDaptomycin can cause skeletal muscle myopathy with elevations in CPK. The percentage of patients treated with daptomycin in phase III trials who experienced … WebDaptomycin is a lipopeptide antibacterial with a spectrum of activity similar to vancomycin but its efficacy against enterococci has not been established. It needs to be given with …

Musculoskeletal toxicities in patients receiving concomitant …

WebDec 28, 2024 · Individually, the incidence of both daptomycin and statin-induced myopathy is rare. While early studies may have shown daptomycin-associated myopathy rates of … WebOct 15, 2024 · Background: Daptomycin-associated myopathy has been identified in 2%-14% of patients, and rhabdomyolysis is a known adverse effect. Although risk factors … opwdd and medical marijuana

Daptomycin - Infectious Diseases - Merck Manuals …

WebApr 2, 2024 · Vancomycin (VCM) and daptomycin (DAP) are standard therapies for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, despite concerns regarding clinical utility and growing resistance. WebMar 1, 2024 · Daptomycin injection is used to treat complicated skin and skin structure infections (cSSSI). It is also used to treat infections in the bloodstream (bacteremia), … WebOct 12, 2024 · Atorvastatin, rosuvastatin, and simvastatin all increased the incidence of DAP-related myopathy and rhabdomyolysis. Conclusion: The mixed approach combining a meta-analysis and disproportionality analysis showed that statin use was associated with the occurrence of DAP-related rhabdomyolysis. opwdd arpa

Does Daptomycin Coadministered with Statins Increase Myopathy …

Daptomycin-Rifampin-Induced Rhabdomyolysis, Acute Renal …

WebJun 6, 2024 · Daptomycin 500mg Powder for Solution for Injection/ Infusion Active Ingredient: daptomycin Company: Panpharma UK Ltd See contact details ATC code: J01XX09 About Medicine Prescription only medicine Healthcare Professionals (SmPC) Patient Leaflet (PIL) This information is for use by healthcare professionals Last updated … WebNational Center for Biotechnology Information opwdd arocWebManufacturer advises monitor plasma creatine phosphokinase (CPK) before treatment and then at least weekly during treatment; monitor CPK more frequently in patients at higher risk of developing myopathy, including those with renal impairment, taking other drugs associated with myopathy, or if CPK elevated more than 5 times upper limit of normal … portsmouth hmo license

"WebOct 10, 2024 · Daptomycin (DAP) is a cyclic lipopeptide antibiotic widely used for patients with methicillin-resistant Staphylococcus aureus infection [1, 2].DAP increases the risk of elevated creatine phosphokinase (CPK) caused by muscle injury, leading to myopathy and rhabdomyolysis in 2%–13% and 5% of the patients, respectively [].Therefore, weekly … " - Daptomycin and myopathy

Daptomycin and myopathy

Early-onset Rhabdomyolysis Associated With Daptomycin

WebDaptomycin for Injection is a lipopeptide antibacterial indicated for the treatment of: Complicated skin and skin structure infections (cSSSI) in adult patients ... Myopathy and rhabdomyolysis: Monitor CPK levels and follow muscle pain or weakness; if elevated CPK or myopathy occurs, consider WebMar 10, 2024 · Myopathy, defined as muscle aching or muscle weakness, in conjunction with increased serum CK concentrations up to 10 times ULN reported in patients …

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WebDaptomycin for Injection is not indicated for the treatment of pneumonia. Daptomycin for Injection is not indicated for the treatment of left-sided infective endocarditis due to . S. … WebFeb 28, 2024 · A drug-induced myopathy is defined as the manifestation of myopathic symptoms occurring in patients without prior muscle disease when exposed to …

WebMar 7, 2024 · INTRODUCTION. Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp … WebApr 1, 2005 · We conclude that daptomycin was the likely cause of our patient's myopathy and possible hepatotoxicity. To our knowledge, this is the only case of daptomycin myopathy with associated liver function abnormalities.

WebDaptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal … WebDaptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal myopathy, patients should be monitored for muscle pain or weakness, and serum creatine kinase levels should be checked weekly.

WebThere have been reports of myopathy, rhabdomyolysis, and increased creatine phosphokinase (CPK) levels in patients taking daptomycin, which increased when daptomycin was given more than once per day.

WebMar 21, 2024 · Daptomycin was discontinued and the patient was started on treatment for rhabdomyolysis. Despite aggressive hydration and diuresis, CPK and urine myoglobin … opwdd article 16WebDaptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal … opwdd article 16 clinic servicesWebDec 19, 2024 · Daptomycin has been associated with clinical myopathy in 2% to 14% of patients. Similarly, statins are associated with myopathy in 5% to 10% of patients. … portsmouth hits cricketWebMar 28, 2024 · Daptomycin is a canonical antibiotic used very commonly in practice for its bactericidal activity against Gram-positive bacteria, including vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, bone infections, skin and soft tissue infections, meningitis, urinary tract infections, and … opwdd application nycWebDaptomycin is a canonical antibiotic used very commonly in practice for its bactericidal activity against Gram-positive bacteria, including vancomycin-resistant enterococci … opwdd article 16 clinic regulationsWebNov 24, 2024 · Daptomycin is a lipopeptide antibiotic that is active against vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). It is less nephrotoxic than vancomycin. … portsmouth history museumWebDaptomycin has excellent coverage against gram-positive bacteria. The adverse effect profile has included rare reports of myopathy and elevated CK levels. Daptomycin is a … opwdd article 16 clinics