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WebFactors that affect distribution. There are many factors that affect a drug's distribution throughout an organism, but Pascuzzo considers that the most important ones are the following: an organism's physical volume, the removal rate and the degree to which a drug binds with plasma proteins and / or tissues.. Physical volume of an organism. This … WebJan 1, 2015 · Host factors such as age, sex, physiological state, diseases of other organ systems, nutritional status, genetic disorders, and tolerance have been identified and reported to affect the efficacy ... com-b behaviour change
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