List of platinum based chemotherapy agents
WebPlatinum-based anticancer drugs, such as cisplatin, are standard chemotherapeutic agents in ovarian cancer therapy. Citation 39 , Citation 40 This class of drugs can penetrate the nucleus of cancer cells and form adducts with genomic or mitochondrial DNA to block the production of DNA, mRNA, and proteins, arrest DNA replication, and activate several … Web3 mrt. 2008 · Unfortunately, resistance has limited the efficacy of these agents in most diseases. Resistance to platinum-based chemotherapy can be intrinsic or acquired and may be mediated by factors outside or within the cancer cell or at its cell membrane. Resistance to platinum chemotherapy is multifactorial (2–6).
List of platinum based chemotherapy agents
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WebIn this network meta-analysis, we found that patients who received a triple combination of platinum-based chemotherapy reported more hematological complications such as anemia and thrombocytopenia but provided relatively higher PFS and OS. In our study, all patients were sensitive to platinum-based chemotherapy during the first-line treatment. Web28 okt. 2024 · Despite significant progress in drug development for advanced prostate cancer patients in the past decade, new active compounds, ideally for molecularly selected patients, are urgently needed. 1,2 Platinum-based compounds have been evaluated in clinical trials and used clinically as monotherapy or in combination with other …
WebL01XA — Platinum compounds. Drugs. Drug. Drug Description. Cisplatin. A platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. Nedaplatin. Used in the treatment of non-small cell lung cancer, small cell lung cancer, oesophygeal cancer, and head and neck cancers . Oxaliplatin. WebDepending on their characteristics and nature of treatment, chemotherapy agents can be categorized as alkylating agents, antimetabolites, anthracyclines, antitumor antibiotics, monoclonal antibodies, platinums, or plant alkaloids. Here, we discuss the main features of each of these categories. Alkylating agents
WebPlatinum-based agents are important drugs or drug candidates for cancer chemotherapy. Traditional platinum drugs including the globally approved cisplatin, carboplatin and … Web14 mei 2024 · Patients enrolled in the study will be eligible to receive 4-6 cycles of platinum-based chemotherapy, and patients without progressive disease (PD) as per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 guidelines (i.e., with an ongoing complete response [CR], partial response [PR], or stable disease) after …
Web1 jul. 2001 · Cisplatin (Platinol) isone of the most active drugs in non-small-cell lung cancer (NSCLC), with asingle-agent response rate of approximately 20%. In many different preclinicalmodels, platinum is synergistic with other chemotherapy drugs and withradiation. The superiority of platinum-containing chemotherapy was suggested bya …
Web• platinum-based chemotherapy regimens – containing a chemotherapy drug known as a “platinum agent” in combination with other chemotherapy drugs and; • non … highlights girls hairWeb17 jul. 2012 · Platinum-based chemotherapy drugs are among the most powerful and widely used against cancer. However, they have toxic side effects, and tumors can become resistant to them. highlights github proWeb8 apr. 2024 · Anti-tumor agent cisplatin has been known to treat . melanoma for the past 30 years; exerting its toxic e ects by forming . ... Concomitant platinum-based chemotherapy or cetuximab with radiotherapy . small police helicopterWeb14 apr. 2024 · Doctors use platinum drugs to treat many kinds of cancer, both alone and in combination with other drugs. Cisplatin, the oldest, has been approved as a cancer treatment since 1978. In the U.S.,... small police department office layoutPlatinum-based antineoplastic drugs (informally called platins) are chemotherapeutic agents used to treat cancer. Their active moieties are coordination complexes of platinum. These drugs are used to treat almost half of people receiving chemotherapy for cancer. In this form of chemotherapy, commonly used drugs include cisplatin, oxaliplatin, and carboplatin, but several have been proposed or are under development. Addition of platinum-based chemotherapy drugs to chemor… small police departments in floridaWebComparison of single agent versus combined chemotherapy in previously treated patients with advanced urothelial carcinoma: a meta-analysis Xiao-Jun Wu, Yi Zhi, Peng He, Xiao … small police shieldWeb28 mrt. 2024 · OPDIVO in combination with fluoropyrimidine- and platinum-based combination chemotherapy is indicated for the first‑line treatment of adult patients with HER2‑negative advanced or metastatic gastric, gastro‑oesophageal junction or oesophageal adenocarcinoma whose tumours express PD-L1 with a combined positive score (CPS) ≥ 5. small police station layout