Ribophagy receptor
Webb8 apr. 2024 · p62蛋白是什么跟自噬相关还是跟癌变相关. p62是异常蛋白的receptor protein,通过C-terminal UBA domain与ubiqutin 发生interact，self-assemble via its N-terminal PB1 domain ,这样就像一个大人一样 ，一手牵着自己一样的蛋白，一手牵着被泛素化的蛋白，形成大的蛋白聚集体，包含着泛素化的蛋白。 WebbThis study suggests a strategy that can be adapted to the identification of additional novel receptor proteins for ribophagy, and identifies a selective autophagy receptor. …
Ribophagy receptor
Did you know?
Webb28 feb. 2024 · In addition, it has been shown recently that mammalian NUFIP1 is a ribophagy receptor required for the selective autophagy of ribosomes during starvation … WebbMCE 引用文献：PMID: 25178155 DRAK2 emerged as a promising drug target for the treatment of autoimmune diseases and to prevent graft rejection after organ transplantation. Screening of a compound library in a DRAK2 binding assay led to the identification of an isothiazolo[5,4-b]pyridine derivative as a novel ligand for DRAK2, …
WebbAutophagy is an evolutionarily conserved and tightly regulated process that plays an important role in maintaining cellular homeostasis. It involves regulation of various genes that function to degrade unnecessary or dysfunctional cellular components, and to recycle metabolic substrates. Autophagy is modulated by many factors, such as nutritional … Webb24 sep. 2010 · The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1. Cell Death Differ 2009; 16: 1006–1017.
WebbWe identify NUFIP1, a protein not previously as- sociated with lysosomes, as necessary for the starvation-induced degradation of ribosomes and show that it fulfills multiple criteria … Webb23 mars 2024 · GSEA results show that these four genes are mainly involved in several neurodegenerative diseases (PD, AD, HD, long-term depression, and ALS), neural function related pathways (neurotrophic signaling pathway, axon guidance, neuroactive ligand receptor interactions, and glycosphingolipid biosynthesis ganglion series), metabolism …
WebbThe ubiquitin–proteasome system (UPS) and autophagy are two distinct and interacting proteolytic systems. They play critical roles in cell survival under normal conditions and during stress. An increasing body of evidence indicates that ubiquitinated cargoes are important markers of degradation. p62, a classical receptor of autophagy, is a …
Webb6 juni 2024 · A recent study published in Science identifies a ribosome receptor required for the autophagic targeting of ribosomes to the lysosome. Autophagy is the catabolic process that delivers cytoplasmic... is boruto gonna be a villainWebbParkinson’s disease (PD) is a pathological condition characterized by the aggregation and the resultant presence of intraneuronal inclusions termed Lewy bodies (LBs) and Lewy neurites which are mainly composed of fibrillar α-synuclein (α-syn) is boruto good right nowWebbAs individuals age, dysfunction of the immune system leads to an increased incidence of infectious disease. Due to the complex network of cellular interactions and the multi-factorial process of aging, numerous impairments in humoral immunity have been reported. Advances in technology have allowed scientists to begin to identify the … is boruto in the infinite tsukuyomiWebb21 jan. 2024 · Identified proteaphagy receptors include Rpn10 in plants, Cue5 in yeast and p62 in mammals. Ribophagy of the small and large ribosomal subunits is induced by different stress conditions in yeast and … is boruto on huluWebb1 apr. 2024 · VLGR1/ADGRV1 (very large G protein-coupled receptor-1) is the largest known adhesion G protein-coupled receptor. Mutations in VLGR1/ADGRV1 cause Usher syndrome (USH), the most common form of hereditary deaf-blindness, and have been additionally linked to epilepsy. Although VLGR1/ADGRV1 is almost ubiquitously expressed, little is … is boruto good yetWebb10 dec. 2024 · Ribophagy Is a Selective Pathway that Degrades Mature Ribosomes upon Starvation Ribophagy, a selective autophagy process specifically targeting ribosome … is boruto more hyuga than uzumakiWebb1) The mTOR complex 1 (mTORC1) is a central mediator in regulating the response to nutrients and growth signaling, and is a key regulator of autophagy.6The localization of … is boruto powerful than naruto