WebbWe first designed SI-109 as a potent, small-molecule inhibitor of the STAT3 SH2 domain. Employing ligands for cereblon/Cullin 4A E3 ligase and SI-109, we obtained a series of … WebbShaomeng Wang serves as the director of the Cancer Drug Discovery program and co-director of the Molecular Therapeutics Program at the University of Michigan …
Wang Lab - University of Michigan
Webb15 maj 2013 · Our study has led to the identification of a set of highly potent MDM2 inhibitors with a stereochemistry that is different from that of our previously reported compounds. The most potent compound (MI-888) binds to MDM2 with a Ki value of 0.44 nM and achieves complete and long-lasting tumor regression in an animal model of … WebbShaomeng Wang's lab University of Michigan (U-M) Overview Advance your research research projects Featured research (4) Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase... grafting wild americans prunus
Diastereomeric spirooxindoles as highly potent and efficacious ... - PubMed
Webb18 feb. 2024 · 2/18/2024. One of our biggest news stories happened as 2024 wound to a close when Roivant Pharma acquired University of Michigan (U-M) startup Oncopia Therapeutics, a targeted protein degradation company co-founded by prolific inventor and U-M Professor Shaomeng Wang. Under the deal, announced December 7, 2024, Roivant … WebbTo accomplish our goals of discovering highly optimized compounds suitable for clinical development and rapidly advancing them into clinical development, Dr. Wang ha s established extensive collaborations with basic scientists, translational scientists and clinical investigators at UMCCC and in other institutions. Webb1 nov. 2024 · Guo G, Li X, Wang Q, Li Y, Chu H, Ma Q, Tu J, Zhang D. IEEE Trans Ultrason Ferroelectr Freq Control, 68(4):1399-1407, 26 Mar 2024 Cited by: 0 articles PMID: 33108285. Polarization-Encrypted Orbital Angular Momentum ... Europe PMC is a service of the Europe PMC Funders' Group, ... china city briarcliff menu